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		<meta data-vue-meta="ssr" property="og:title" content="Alkeus’ Oral Gildeuretinol for GA Shows Positive Topline Results in Phase III | Market Scope" data-vmid="og:title"><meta data-vue-meta="ssr" property="og:description" content="Alkeus Pharmaceuticals reported positive topline results on Oct. 23 from the Phase III SAGA trial of gildeuretinol acetate (ALK-001), a once-daily oral therapy candidate targeting geographic atrophy (GA). Alkeus, of Cambridge, Massachusetts, said ALK-001 showed a statistically significant reduction in the GA lesion growth rate of 15.3 percent vs. placebo from six to 24 months. The study’s primary endpoint was the reduction in GA lesion growth rate from baseline to 24 months, and ALK-001 demon..." data-vmid="og:description"><meta data-vue-meta="ssr" property="og:url" content="//www.market-scope.com/pages/news/7984/alkeus-oral-gildeuretinol-for-ga-shows-positive-topline-results-in-phase-iii" data-vmid="og:url"><meta data-vue-meta="ssr" property="og:type" content="article" data-vmid="og:type"><meta data-vue-meta="ssr" property="article:published_time" content="2024-11-01T00:00:00.000Z" data-vmid="article:published_time"><meta data-vue-meta="ssr" name="image" property="og:image" content="https://www.market-scope.com/files/uploads/images/2021/07/Alkeus%20logo.jpg" data-vmid="og:image"><meta data-vue-meta="ssr" name="author" content="Jennie Crabbe" data-vmid="author"><meta data-vue-meta="ssr" name="description" content="Alkeus Pharmaceuticals reported positive topline results on Oct. 23 from the Phase III SAGA trial of gildeuretinol acetate (ALK-001), a once-daily oral thera..." data-vmid="description">
		<title>Alkeus’ Oral Gildeuretinol for GA Shows Positive Topline Results in Phase III | Market Scope</title>
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All Rights reserved.</p></footer></div> <!----> <!----> <!----></div> <div id="invisible-recaptcha" data-sitekey="6LcfrXEUAAAAAL8oovQG9EMVvWYIrcgcHP2eWtjb" class="g-recaptcha g-recaptcha--left g-recaptcha--mobile-hidden g-recaptcha--desktop-hidden"></div> <!----></div><script>window.__INITIAL_STATE__={"companyNames":[],"articles":[],"article":{"id":7984,"position":1439,"enabled":1,"draft":0,"author_uid":5164,"author_custom":"","title":"Alkeus’ Oral Gildeuretinol for GA Shows Positive Topline Results in Phase III","slug_auto":"alkeus-oral-gildeuretinol-for-ga-shows-positive-topline-results-in-phase-iii","slug_override":null,"slug_history":null,"meta_title":null,"content":"\u003Chtml\u003E\u003Cbody\u003E\u003Cp style=\"text-align:center\"\u003E\u003Cimg alt=\"Alkeus&rsquo; Oral Gildeuretinol for GA Shows Positive Topline Results in Phase III\" height=\"159\" src=\"\u002Ffiles\u002Fuploads\u002Fimages\u002F2021\u002F07\u002FAlkeus%20logo.jpg\" width=\"381\" class=\"img-thumbnail \"\u003E\u003C\u002Fp\u003E\r\n\r\n\u003Cp\u003EAlkeus Pharmaceuticals reported positive topline results on Oct. 23 from the Phase III SAGA trial of gildeuretinol acetate (ALK-001), a once-daily oral therapy candidate targeting geographic atrophy (GA).\u003C\u002Fp\u003E\r\n\r\n\u003Cp\u003EAlkeus, of Cambridge, Massachusetts, said ALK-001 showed a statistically significant reduction in the GA lesion growth rate of 15.3 percent vs. placebo from six to 24 months.\u003C\u002Fp\u003E\r\n\r\n\u003Cp\u003EThe study&rsquo;s primary endpoint was the reduction in GA lesion growth rate from baseline to 24 months, and ALK-001 demonstrated a clinically meaningful reduction of 13.4 percent for that time range.\u003C\u002Fp\u003E\r\n\r\n\u003Cp\u003EALK-001 also slowed the decline in visual function, with 4.4 fewer letters lost in low luminance visual acuity over 24 months. Additionally, among participants at risk of developing choroidal neovascularization or wet age-related macular degeneration, only 11 percent in the gildeuretinol group experienced these adverse events, compared with 44 percent in the placebo group.\u003C\u002Fp\u003E\r\n\r\n\u003Cp\u003EALK-001 is designed to reduce the dimerization of vitamin A and prevent retinal degeneration. It is being investigated in GA and Stargardt disease.\u003C\u002Fp\u003E\r\n\u003C\u002Fbody\u003E\u003C\u002Fhtml\u003E\n","content_hub":null,"content_img_sources":["\u002Ffiles\u002Fuploads\u002Fimages\u002F2021\u002F07\u002FAlkeus%20logo.jpg"],"share_img_filename":null,"preview_img_blurhash":"LbR37t-U-pf+M{n$xafl_NIoM{t7","preview_img_width":494,"preview_img_height":206,"meta_description":null,"allowed_roles":"24","inherit_specialty_descendents":1,"rules":[],"publish_date":"2024-11-01","qdrant_id":null,"entities":[{"text":"Cambridge, Massachusetts","type":"location"},{"text":"placebo","type":"medication"},{"text":"ALK-001","type":"medication"},{"text":"Alkeus Pharmaceuticals","type":"organization"},{"text":"choroidal neovascularization","type":"symptom"},{"text":"wet age-related macular degeneration","type":"symptom"},{"text":"adverse events","type":"symptom"}],"landing_tags":[{"id":33,"namespace":null,"slug":"breaking","label":"Breaking","counter":5271,"created":"2018-09-26T07:21:07+00:00","modified":"2026-10-02T15:30:59+00:00","color":"#07636d"},{"id":100,"namespace":null,"slug":"clinical-trial","label":"Clinical Trial","counter":582,"created":"2019-08-09T16:44:56+00:00","modified":"2026-10-02T15:07:00+00:00","color":"#b76c03"},{"slug":"ophthalmic","label":"Ophthalmic","color":"#0f9b07"},{"id":51,"namespace":null,"slug":"pharma","label":"Pharma","counter":1153,"created":"2018-09-26T21:10:16+00:00","modified":"2026-10-02T15:21:14+00:00","color":"#063768"},{"id":89,"namespace":null,"slug":"retina","label":"Retina","counter":2179,"created":"2019-07-12T20:57:58+00:00","modified":"2026-10-02T15:16:48+00:00","color":"#0d967d"}],"recommended_products":[{"id":388,"slug_override":null,"available":1,"document_original_filename":"2023-United-States-Retina-Atlas.pdf","document_sample_filename":null,"document_cover_filename":null,"_joinData":{"id":8740,"article_id":7984,"product_id":388,"created":"2024-11-01T17:06:49+00:00","modified":"2024-11-01T17:06:49+00:00"},"product_type":{"id":1,"slug":"ophthalmic-comprehensive-reports","name":"Ophthalmic Comprehensive Reports","attributes_separator":", ","pricing_models":[{"month_interval":0,"_joinData":{"id":1,"pricing_model_id":1,"product_type_id":1}}],"plans":[]},"product_type_attributes":[{"product_type_id":1,"attribute":"topic","_joinData":{"id":934,"product_type_attribute_id":1,"product_id":388,"value":"2023 United States Retina Atlas Featuring the Market Scope Exclusive MedOp Index™ Analysis"}},{"product_type_id":1,"attribute":"month","_joinData":{"id":935,"product_type_attribute_id":2,"product_id":388,"value":"June"}},{"product_type_id":1,"attribute":"year","_joinData":{"id":936,"product_type_attribute_id":3,"product_id":388,"value":"2023"}}],"product_skus":[{"product_id":388}],"tag_list":[],"label":"2023 United States Retina Atlas Featuring the Market Scope Exclusive MedOp Index™ Analysis, June, 2023","slug":"2023-united-states-retina-atlas-featuring-the-market-scope-exclusive-medop-index-analysis-june-2023"},{"id":593,"slug_override":null,"document_original_filename":"2026-Retina-Disease-Model-Cover.pdf","document_cover_filename":null,"document_sample_filename":null,"product_type":{"id":1,"slug":"ophthalmic-comprehensive-reports","name":"Ophthalmic Comprehensive Reports","attributes_separator":", ","pricing_models":[{"month_interval":0,"_joinData":{"id":1,"pricing_model_id":1,"product_type_id":1}}]},"product_type_attributes":[{"product_type_id":1,"attribute":"topic","_joinData":{"id":1443,"product_type_attribute_id":1,"product_id":593,"value":"2026 Retinal Disease Model"}},{"product_type_id":1,"attribute":"month","_joinData":{"id":1444,"product_type_attribute_id":2,"product_id":593,"value":"September"}},{"product_type_id":1,"attribute":"year","_joinData":{"id":1445,"product_type_attribute_id":3,"product_id":593,"value":"2026"}}],"tag_list":[],"label":"2026 Retinal Disease Model, September, 2026","slug":"2026-retinal-disease-model-september-2026"},{"id":592,"slug_override":null,"document_original_filename":"2026-Nonexudative-Retinal-Disease-Pharmaceuticals-Market-Report.pdf","document_cover_filename":"2026 Nonexudative Retina Pharma Cover - 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